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The Buffalo Bills scored 34 unanswered points to win 34-10 over the Tennessee Titans on Sunday at Highmark Stadium.

After the Titans took a 10-0 lead early in the second quarter, the offense sputtered while the defense relented. Buffalo scored in all five second-half possessions as the home team took control.

In his first start with the Titans, Mason Rudolph was 25-of-40 for 215 yards with a touchdown and an interception.

Buffalo’s Josh Allen finished with 323 passing yards and two touchdowns, while rookie Keon Coleman caught four passes for 125 yards.

Tennessee (1-5) has its worst start since 2015. Follow the Tennessean’s live Titans game updates below:

Tennessee Titans vs. Buffalo Bills: Live updates, highlights from NFL Week 7 game

GENTRY ESTES: Same song, new verse: Tennessee Titans start strong, fade in loss at Buffalo Bills

TITANS-BILLS KEY MOMENTS: How Tennessee Titans were embarrassed by Buffalo Bills

INSTANT ANALYSIS: New QB, same result as Mason Rudolph-led Tennessee Titans blunder through loss to Bills

L’JARIUS SNEED, WILL LEVIS OUT: L’Jarius Sneed, Will Levis injury updates: See Tennessee Titans inactives vs Buffalo Bills

Some notes from Brian Callahan’s post-game press conference:

• Callahan liked how Titans ran the ball in the first half and took the chance to go for 4th and 2 early in the second half.
• Callahan had long explanation for Levis’ status changing during the week, saying that Levis’ shoulder bothered him late in Colts loss and on Wednesday. Levis was limited in practice on Wednesday, but was listed as a full participant on Thursday. “It didn’t feel great,” Callahan said. Then Levis was limited on Friday and designated as questionable. He’ll be week-to-week going forward.
• Callahan acknowledged the issues at right tackle and says the team is rolling through the available options with no good answer yet. Nicholas Petit-Frere allowed multiple pressures and at least one sack working against Gregory Rousseau and the Bills front after Jaelyn Duncan left the game with a hamstring injury after the opening drive.

Buffalo adds another touchdown late, on a Ray Davis 16-yard touchdown run. Buffalo finishes the game by scoring 34 unanswered points in the ugliest game of a disappointing season to date.

There are several questions for Brian Callahan to answer, about the fourth-down decision, Will Levis’ status and the overall second-half failure.

A Keon Coleman catch originally ruled as a touchdown on 3rd and goal is overturned upon review, so the Bills settle on a Tyler Bass 30-yard field goal.

Tennessee is now down by three scores, staring into a 1-5 record.

Buffalo has 215 total yards in the second half and has scored in each second-half possession. Josh Allen is up to 256 passing yards and two touchdowns.

Josh Allen finds Ty Johnson for a 4-yard touchdown pass to extend Buffalo’s lead. PAT good.

The Bills have scored 24 unanswered points and 17 points on three drives in the second half. Ugly, ugly football from the Titans.

After a lengthy review, Dalton Kincaid’s 25-yard catch to set up 1st and goal stands. (Titans keep the timeout after the challenge due to the change from down-by-contact to a fumble out of bounds for Kincaid when he landed on the ground, but it does not materially change the situation.)

Buffalo will have 2nd and goal from inside the Titans’ 5-yard line when the fourth quarter begins. Tennessee’s defense needs to make a big play and soon.

Buffalo adds three more points on a Tyler Bass 28-yard field goal. Key plays on the drive included an Amari Cooper 19-yard catch against Jarvis Brownlee and a Jeffery Simmons offside penalty on 3rd and 1 after it appeared Josh Allen was short on a sneak.

Still, it was key for the Titans defense to hold the Bills to a field goal. Still a one-score game.

Kenneth Murray stays down after a Ray Davis catch, and he gets up after being looked at by Titans personnel.

Moments later, Murray went into the Titans locker room after spending time in the injury tent. He’s walking under his own power.

UPDATE: The Titans say Murray is questionable to return with a shoulder injury.

Gregory Rousseau has been wearing out Nicholas Petit-Frere all game, and he finally gets to Mason Rudolph for a sack. It all but halts the Titans drive at midfield after a DPI drawn by Calvin Ridley earlier in the possession.

Tennessee punts the ball away, and it feels like the Titans defense must get a stop here. Even with Rudolph’s efficiency, this has not been an explosive offense. The Titans aren’t currently capable of erasing double-digit deficits.

Josh Allen and the Bills offense quickly takes advantage of the good field position. Allen finds Keon Coleman and Dalton Kincaid for first-down gains, then finds an open Amari Cooper in the back of the end zone for a 12-yard touchdown pass. PAT good.

Just like that, Tennessee is behind. Rough start to the third quarter.

After a Mason Rudolph second-down scramble for 9 yards, Tony Pollard loses a yard on 3rd and 1 near the Titans’ 44-yard line. Tennessee’s offense stays on the field on 4th and 2, and Tony Pollard again loses a yard on a run that had no chance.

Not only was the decision by Brian Callahan ill-advised, but the playcalling left a lot to be desired. Titans defense is going to be asked to hold again.

Titans stats

• Mason Rudolph: 18-23, 155 yards, TD
• Tony Pollard: 11 carries, 65 yards
• Chig Okonkwo: 3 catches, 42 yards
• Calvin Ridley: 2 catches, 33 yards
• Tyler Boyd: 4 catches, 31 yards
• DeAndre Hopkins: 1 catch, 6 yards
• Nick Westbrook-Ikhine: 2 catches, 10 yards, TD
• Harold Landry: 2 total tackles, TFL, pass defended

Bills stats

• Josh Allen: 4-11, 65 yards; 1 carry, 7 yards
• James Cook: 6 carries, 26 yards, TD
• Keon Coleman: 1 catch, 44 yards
• AJ Epenesa: 2 total tackles, sack, forced fumble, pass defended

Very good half for the Titans, but the lead is only 10-7. Tennessee will receive the second-half kickoff.

First half stats upcoming.

Mason Rudolph is sacked by Buffalo’s AJ Epenesa via Rudolph’s blindside, and the ball is loose. After a couple bounces, Lloyd Cushenberry recovers. It’s a 20-yard loss, but a key recovery given that the Titans are deep in their own territory.

Tennessee’s defense holds, helped by Arden Key’s first sack of the season. The Bills punt the ball away. Titans defense has been stingy in the first half.

The good news: Tony Pollard passed the concussion check and returned to the game.

The bad news: A mishandled snap between Mason Rudolph and Lloyd Cushenberry results in a fumble and Bills recovery in Tennessee territory. Buffalo’s Terrel Bernard makes the recovery.

Josh Allen finds Keon Coleman wide open over the middle for a 44-yard catch and run, and James Cook scores on the next play via a 11-yard touchdown run. PAT good.

Buffalo goes 61 yards in three plays for the touchdown. Game on.

On 3rd and goal, Mason Rudolph has time and room to scramble, and he eventually finds Nick Westbrook-Ikhine for a 3-yard touchdown pass. PAT good.

This is all about the Titans offensive line owning the line of scrimmage. Rudolph has not been sacked, and the Titans have 49 rushing yards on nine carries.

Tony Pollard walks off and goes to the injury tent after being hit in the head by Buffalo CB Taron Johnson, which produces a flag on third down to extend the drive. Julius Chestnut is the only other active Titans running back available. Titans are driving after the personal foul penalty by Johnson, now 1st and goal.

The Titans defense has come to play, shutting down the Bills for three 3-and-outs in three possessions. Josh Allen is 1-of-5 for 5 yards.

For Buffalo, WR Curtis Samuel is questionable to return with a shoulder injury.

Titans drive 61 yards in 13 plays to open the scoring with a Nick Folk 25-yard field goal. Mason Rudolph has been steady, completing passes to Nick Westbrook-Ikhine and Tyler Boyd on third down to move the chains on the drive. But his 3rd and 12 pass to Boyd was short of the line to gain, leading to the Folk FG.

Tennessee’s offense looks steadier with Rudolph at QB, but not necessarily more explosive. No targets yet for DeAndre Hopkins.

Nicholas Petit-Frere is in on the Titans’ second offensive drive for Jaelyn Duncan, who is questionable to return with a hamstring injury. Tennessee’s right tackle conundrum continues.

Mason Rudolph opens with a couple of easy throws to tight ends, including one to Josh Whyle for a first down. But Rudolph’s third down pass for Calvin Ridley is incomplete.

Good start for the Titans defense, helped in part by an Amari Cooper third-down drop. Bills go 3-and-out.

Titans will be backed up in their own territory after a penalty on the punt.

Josh Allen and the Bills offense will get the ball first. How will the Titans defense fare without L’Jarius Sneed?

Jaelyn Duncan is working at right tackle during pregame warmups with the rest of the starting offensive line, so it appears he’ll start today.

It’s a very newsy inactives list for the Tennessee Titans ahead of today’s game. The full list:

• DL Keondre Coburn
• QB Will Levis
• TE David Martin-Robinson
• LB Caleb Murphy
• CB L’Jarius Sneed
• RB Tyjae Spears
• OL Leroy Watson

Levis is inactive, meaning Trevor Siemian will back up Mason Rudolph. Sneed was listed as questionable with a quad injury. Watson started last week at right tackle but won’t be available on Sunday.

Bills inactives:

• LB Joe Andreessen
• OL Will Clapp
• DB Mike Edwards
• DL Zion Logue
• LB Eddie Ulofoshio

The Tennessee Titans vs. Buffalo Bills game will broadcast live on CBS, with streaming options available on Fubo, which offers a free trial to potential subscribers.

Watch Titans vs. Colts live on Fubo (free trial)

• Play-by-play: Andrew Catalon
• Analyst: Jason McCourty and Tiki Barber
• Sideline reporter: AJ Ross

Odds according to BetMGM on Saturday, Oct. 19

• ODDS:  Bills by 9.5
• O/U:  41 points
• MONEY LINE: Bills -500, Titans +375

Titans beat reporter Nick Suss’ prediction: Buffalo Bills 20, Tennessee Titans 13

Until the Titans’ offense proves it’s a threat, it’s hard to think the results are going to look any different. The Bills are really good at home. Allen is a different caliber of quarterback than the Titans have dealt with all year. And it’s just hard to foresee this team traveling to Buffalo and pulling off the upset when the Bills have played pretty well in close games and the Titans simply haven’t.

Inactives will be announced at 10:30 a.m. CT on Sunday. For now, here’s the full injury report for the two teams heading into the game.

Titans injury report

• DL Keondre Coburn (knee) — Out
• LB Cedric Gray (shoulder) — Out
• RB Tyjae Spears (hamstring) — Out
• WR Treylon Burks (knee) — Out
• QB Will Levis (shoulder) — Questionable (reportedly won’t start)
• CB L’Jarius Sneed (quad) — Questionable

Bills injury report

• RB Darrynton Evans (hamstring) — Doubtful
• RB Ray Davis (calf) — Questionable
• DB Mike Edwards (illness) — Questionable

Tickets for Sunday’s game on StubHub are priced from $147 before fees.

The National Weather Service forecast for Sunday in Orchard Park calls for a pretty nice afternoon, with temperatures at 65 degrees at kickoff with a relatively calm wind and no chances for precipitation. The high temperature for Sunday is forecasted at 69 degrees.

All times central

Regular season

• Week 1 (Sept. 8): at Chicago Bears, L 24-17
• Week 2 (Sept. 15): New York Jets, L 24-17
• Week 3 (Sept. 22): Green Bay Packers, L 30-14 
• Week 4 (Sept. 30): at Miami Dolphins, W 31-12
• Week 5: OPEN DATE
• Week 6 (Oct. 13): Indianapolis Colts, L 20-17 (Record: 1-4)
• Week 7 (Oct. 20): at Buffalo Bills, Noon on CBS
• Week 8 (Oct. 27): at Detroit Lions, Noon on FOX
• Week 9 (Nov. 3): New England Patriots, Noon on FOX
• Week 10 (Nov. 10): at Los Angeles Chargers, 3:05 p.m. on FOX
• Week 11 (Nov. 17): Minnesota Vikings, Noon on CBS
• Week 12 (Nov. 24): at Houston Texans, Noon on CBS
• Week 13 (Dec. 1): at Washington Commanders, Noon on FOX
• Week 14 (Dec. 8): Jacksonville Jaguars, Noon on CBS
• Week 15 (Dec. 15): Cincinnati Bengals, Noon on FOX
• Week 16 (Dec. 22): at Indianapolis Colts, Noon on CBS
• Week 17 (Dec. 29): at Jacksonville Jaguars, Noon on CBS
• Week 18 (Jan. 4/5): Houston Texans, TBD

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